Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin.

ABSTRACT: Salvianolic acid B is an antioxidative ingredient derived from Radix Salviae miltiorrhizae that has been widely used to treat liver diseases. However, the therapeutic mechanism underlying Salvianolic acid B has remained largely unknown. Our studies verified that Salvianolic acid B efficiently blocked mitochondrial deformation and dysfunction induced by H₂O₂ in the human hepatocyte cell line HL7702. Mortalin, a mitochondrial molecular chaperone, maintains mitochondrial morphology stabilization and function integrity. Previous results showed that mortalin overexpression has been observed in hematoma carcinoma cells and that mortalin maintains mitochondrial homeostasis and antagonizes oxidative stress damage. We found that Salvianolic acid B significantly up-regulated mo

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5333085 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature