Parallel changes in serum proteins and diffusion tensor imaging in methamphetamine-associated psychosis.

ABSTRACT: Methamphetamine-associated psychosis (MAP) involves widespread neurocognitive and molecular deficits, however accurate diagnosis remains challenging. Integrating relationships between biological markers, brain imaging and clinical parameters may provide an improved mechanistic understanding of MAP, that could in turn drive the development of better diagnostics and treatment approaches. We applied selected reaction monitoring (SRM)-based proteomics, profiling 43 proteins in serum previously implicated in the etiology of major psychiatric disorders, and integrated these data with diffusion tensor imaging (DTI) and psychometric measurements from patients diagnosed with MAP (N = 12), methamphetamine dependence without psychosis (MA; N = 14) and healthy controls (N = 16). Protein analysis ident

SUBMITTER: Breen MS 

PROVIDER: S-EPMC5333148 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature