Genome-wide transcriptomics of aging in the rotifer Brachionus manjavacas, an emerging model system.

ABSTRACT:

Background

Understanding gene expression changes over lifespan in diverse animal species will lead to insights to conserved processes in the biology of aging and allow development of interventions to improve health. Rotifers are small aquatic invertebrates that have been used in aging studies for nearly 100 years and are now re-emerging as a modern model system. To provide a baseline to evaluate genetic responses to interventions that change health throughout lifespan and a framework for new hypotheses about the molecular genetic mechanisms of aging, we examined the transcriptome of an asexual female lineage of the rotifer Brachionus manjavacas at five life stages: eggs, neonates, and early-, late-, and post-reproductive adults.

Results

There are widespread shifts in gene ex

SUBMITTER: Gribble KE 

PROVIDER: S-EPMC5333405 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature