Identification of somatic mutations using whole-exome sequencing in Korean patients with acute myeloid leukemia.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a biologically and clinically heterogeneous cancer of the bone marrow that is characterized by the rapid growth of abnormal myeloid cells.

Methods

We performed a mutational analysis to identify AML somatic mutations using the whole-exome sequencing data of 36 tumor-normal sample pairs from Korean patients with de novo AML. We explored the functional impact of the genes identified in the mutational analyses through an integrated Gene Ontology (GO) and pathway analysis.

Results

A total of 11 genes, including NEFH (p = 6.27 × 10^-13 and q = 1.18 × 10^-8) and TMPRSS13 (p = 1.40 × 10^-10 and q = 1.32 × 10^-6), also demonstrated q values less than 0.1 in 36 Korean AML patients. Five out of th

SUBMITTER: Heo SG 

PROVIDER: S-EPMC5333433 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature