Lesion localization of speech comprehension deficits in chronic aphasia.

ABSTRACT:

Objective

Voxel-based lesion-symptom mapping (VLSM) was used to localize impairments specific to multiword (phrase and sentence) spoken language comprehension.

Methods

Participants were 51 right-handed patients with chronic left hemisphere stroke. They performed an auditory description naming (ADN) task requiring comprehension of a verbal description, an auditory sentence comprehension (ASC) task, and a picture naming (PN) task. Lesions were mapped using high-resolution MRI. VLSM analyses identified the lesion correlates of ADN and ASC impairment, first with no control measures, then adding PN impairment as a covariate to control for cognitive and language processes not specific to spoken language.

Results

ADN and ASC deficits were associated with lesions in a distrib

SUBMITTER: Pillay SB 

PROVIDER: S-EPMC5333516 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature