Ontology highlight
ABSTRACT:
SUBMITTER: Godfrey L
PROVIDER: S-EPMC5333536 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Godfrey Laura L Kerry Jon J Thorne Ross R Repapi Emmanouela E Davies James O J JO Tapia Marta M Ballabio Erica E Hughes Jim R JR Geng Huimin H Konopleva Marina M Milne Thomas A TA
Experimental hematology 20161114
Survival rates for children and adults carrying mutations in the Mixed Lineage Leukemia (MLL) gene continue to have a very poor prognosis. The most common MLL mutation in acute lymphoblastic leukemia is the t(4;11)(q21;q23) chromosome translocation that fuses MLL in-frame with the AF4 gene producing MLL-AF4 and AF4-MLL fusion proteins. Previously, we found that MLL-AF4 binds to the BCL-2 gene and directly activates it through DOT1L recruitment and increased H3K79me2/3 levels. In the study descri ...[more]