Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium.

ABSTRACT:

Background

Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify novel genes that interact with ever active tobacco smoking in adult onset asthma.

Methods

We performed a genome-wide interaction analysis in six studies participating in the GABRIEL consortium following two meta-analyses approaches based on 1) the overall interaction effect and 2) the genetic effect in subjects with and without smoking exposure. We performed a discovery meta-analysis including 4,057 subjects of European descent and replicated our findings in an independent cohort (LifeLines Cohort Study), including 12,475 subjects.

Results

First approach: 50 SNPs were selected

SUBMITTER: Vonk JM 

PROVIDER: S-EPMC5333809 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature