The association between osteopontin gene polymorphisms, osteopontin expression and sarcoidosis.

ABSTRACT:

Background

Sarcoidosis is a systemic inflammatory disease of unknown etiology. Osteopontin (SPP1, OPN) is an extra cellular matrix glycoprotein and cytokine with a known role in granuloma formation and in autoimmune and inflammatory diseases.

Objective

To determine whether plasma OPN levels are elevated in patients with sarcoidosis and compare the frequency of four single nucleotide polymorphism (SNPs) variants in the OPN gene in sarcoidosis patients compared to healthy controls.

Methods

Demographic and clinical information, radiological studies and pulmonary function tests were evaluated in 113 patients with sarcoidosis and in 79 healthy controls. Blood samples were analyzed for SNPs of the OPN gene and for plasma OPN and CRP levels. Association between clinical feat

SUBMITTER: Lavi H 

PROVIDER: S-EPMC5333822 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature