Sox10 contributes to the balance of fate choice in dorsal root ganglion progenitors.

ABSTRACT: The development of functional peripheral ganglia requires a balance of specification of both neuronal and glial components. In the developing dorsal root ganglia (DRGs), these components form from partially-restricted bipotent neuroglial precursors derived from the neural crest. Work in mouse and chick has identified several factors, including Delta/Notch signaling, required for specification of a balance of these components. We have previously shown in zebrafish that the Sry-related HMG domain transcription factor, Sox10, plays an unexpected, but crucial, role in sensory neuron fate specification in vivo. In the same study we described a novel Sox10 mutant allele, sox10baz1, in which sensory neuron numbers are elevated above those of wild-types. Here we investigate the origin of this neur

SUBMITTER: Delfino-Machin M 

PROVIDER: S-EPMC5333849 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature