Feasibility of the TBDx automated digital microscopy system for the diagnosis of pulmonary tuberculosis.

ABSTRACT:

Background

Improved and affordable diagnostic or triage tests are urgently needed at the microscopy centre level. Automated digital microscopy has the potential to overcome issues related to conventional microscopy, including training time requirement and inconsistencies in results interpretation.

Methods

For this blinded prospective study, sputum samples were collected from adults with presumptive pulmonary tuberculosis in Lima, Peru and Ho Chi Minh City, Vietnam. TBDx performance was evaluated as a stand-alone and as a triage test against conventional microscopy and Xpert, with culture as the reference standard. Xpert was used to confirm positive cases.

Findings

A total of 613 subjects were enrolled between October 2014 and March 2015, with 539 included in the final

SUBMITTER: Nabeta P 

PROVIDER: S-EPMC5333855 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature