Age-related changes in CD4+CD25+FOXP3+ regulatory T cells and their relationship with lung cancer.

ABSTRACT:

Objectives

CD4+CD25+FOXP3+ regulatory T cells (Treg) inhibit the anti-tumour immune response and reduce the effect of cancer immunotherapy. Although studies have demonstrated that the number and suppressive activity of Treg increase with age, it is not clear whether these changes correlate with a higher incidence of tumours in the elderly. This study was designed to explore the relationship between increase in CD4+CD25+FOXP3+ Treg and the higher risk of lung cancer in the elderly.

Methods

Seventy lung cancer patients and 60 sex- and age-matched controls were recruited. Both groups were divided into three subgroups based on their age (young, middle-aged, or elderly). The proportion of CD4+CD25+FOXP3+ /CD4+ T cells was detected using flow cytometry, and the level of FOXP3 mRNA

SUBMITTER: Hou PF 

PROVIDER: S-EPMC5333862 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature