A 4DCT imaging-based breathing lung model with relative hysteresis.

ABSTRACT: To reproduce realistic airway motion and airflow, the authors developed a deforming lung computational fluid dynamics (CFD) model based on four-dimensional (4D, space and time) dynamic computed tomography (CT) images. A total of 13 time points within controlled tidal volume respiration were used to account for realistic and irregular lung motion in human volunteers. Because of the irregular motion of 4DCT-based airways, we identified an optimal interpolation method for airway surface deformation during respiration, and implemented a computational solid mechanics-based moving mesh algorithm to produce smooth deforming airway mesh. In addition, we developed physiologically realistic airflow boundary conditions for both models based on multiple images and a single image. Furthermore, we exami

SUBMITTER: Miyawaki S 

PROVIDER: S-EPMC5333919 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature