Identification of a characteristic vascular belt zone in human colorectal cancer.

ABSTRACT:

Blood vessels in cancer

Intra-tumoral blood vessels are of supreme importance for tumor growth, metastasis and therapy. Yet, little is known about spatial distribution patterns of these vessels. Most experimental or theoretical tumor models implicitly assume that blood vessels are equally abundant in different parts of the tumor, which has far-reaching implications for chemotherapy and tumor metabolism. In contrast, based on histological observations, we hypothesized that blood vessels follow specific spatial distribution patterns in colorectal cancer tissue. We developed and applied a novel computational approach to identify spatial patterns of angiogenesis in histological whole-slide images of human colorectal cancer.

A characteristic spatial pattern of blood vessels in colore

SUBMITTER: Kather JN 

PROVIDER: S-EPMC5333981 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature