Pharmacokinetic Evaluation of the Tau PET Radiotracer ¹⁸F-T807 (¹⁸F-AV-1451) in Human Subjects.

ABSTRACT: ¹⁸F-T807 is a PET radiotracer developed for imaging tau protein aggregates, which are implicated in neurologic disorders including Alzheimer disease and traumatic brain injury (TBI). The current study characterizes ¹⁸F-T807 pharmacokinetics in human subjects using dynamic PET imaging and metabolite-corrected arterial input functions. Methods: Nine subjects (4 controls, 3 with a history of TBI, 2 with mild cognitive impairment due to suspected Alzheimer disease) underwent dynamic PET imaging for up to 120 min after bolus injection of ¹⁸F-T807 with arterial blood sampling. Total volume of distribution (V_T) was estimated using compartmental modeling (1- and 2-tissue configurations) and graphical analysis techniques (Logan and multiline

SUBMITTER: Wooten DW 

PROVIDER: S-EPMC5334185 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature