Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer.

ABSTRACT:

Purpose

The PI3K/Akt signaling axis contributes to the dysregulation of many dominant features in breast cancer including cell proliferation, survival, metabolism, motility, and genomic instability. While multiple studies have demonstrated that basal-like or triple-negative breast tumors have uniformly high PI3K/Akt activity, genomic alterations that mediate dysregulation of this pathway in this subset of highly aggressive breast tumors remain to be determined.

Methods

In this study, we present an integrated genomic analysis based on the use of a PI3K gene expression signature as a framework to analyze orthogonal genomic data from human breast tumors, including RNA expression, DNA copy number alterations, and protein expression. In combination with data from a genome-wide RN

SUBMITTER: Mehta GA 

PROVIDER: S-EPMC5334195 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature