Hierarchical organization of the hemostatic response to penetrating injuries in the mouse macrovasculature.

ABSTRACT: Essentials Methods were developed to image the hemostatic response in mouse femoral arteries in real time. Penetrating injuries produced thrombi consisting primarily of platelets. Similar to arterioles, a core-shell architecture of platelet activation occurs in the femoral artery. Differences from arterioles included slower platelet activation and reduced thrombin dependence.

Summary

Background Intravital studies performed in the mouse microcirculation show that hemostatic thrombi formed after penetrating injuries develop a characteristic architecture in which a core of fully activated, densely packed platelets is overlaid with a shell of less activated platelets. Objective Large differences in hemodynamics and vessel wall biology distinguish arteries from arterioles. Here we asked

SUBMITTER: Welsh JD 

PROVIDER: S-EPMC5334252 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature