Whole genome sequencing analysis of lung adenocarcinoma in Xuanwei, China.

ABSTRACT:

Background

The lung cancer mortality rate in Xuanwei city is among the highest in China and adenocarcinoma is the major histological type. Lung cancer has been associated with exposure to indoor smoky coal emissions that contain high levels of polycyclic aromatic hydrocarbons; however, the pathogenesis of lung cancer has not yet been fully elucidated.

Methods

We performed whole genome sequencing with lung adenocarcinoma and corresponding non-tumor tissue to explore the genomic features of Xuanwei lung cancer. We used the Molecule Annotation System to determine and plot alterations in genes and signaling pathways.

Results

A total of 3 428 060 and 3 416 989 single nucleotide variants were detected in tumor and normal genomes, respectively. After comparison of these two

SUBMITTER: Wang X 

PROVIDER: S-EPMC5334298 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature