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Lipid quantitation and metabolomics data from vitamin E-deficient and -sufficient zebrafish embryos from 0 to 120 hours-post-fertilization.

ABSTRACT: The data herein is in support of our research article by McDougall et al. (2017) [1], in which we used our zebrafish model of embryonic vitamin E (VitE) deficiency to study the consequences of VitE deficiency during development. Adult 5D wild-type zebrafish (Danio rerio), fed defined diets without (E-) or with VitE (E+, 500 mg RRR-?-tocopheryl acetate/kg diet), were spawned to obtain E- and E+ embryos that we evaluated using metabolomics and specific lipid analyses (each measure at 24, 48, 72, 120 hours-post-fertilization, hpf), neurobehavioral development (locomotor responses at 96 hpf), and rescue strategies. Rescues were attempted using micro-injection into the yolksac using VitE (as a phospholipid emulsion containing d6-?-tocopherol at 0 hpf) or D-glucose (in saline at 24 hpf).

SUBMITTER: McDougall M 

PROVIDER: S-EPMC5334496 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Lipid quantitation and metabolomics data from vitamin E-deficient and -sufficient zebrafish embryos from 0 to 120 hours-post-fertilization.

McDougall Melissa M   Choi Jaewoo J   Kim Hye-Kyeong HK   Bobe Gerd G   Stevens J Frederik JF   Cadenas Enrique E   Tanguay Robert R   Traber Maret G MG  

Data in brief 20170221

The data herein is in support of our research article by McDougall et al. (2017) [1], in which we used our zebrafish model of embryonic vitamin E (VitE) deficiency to study the consequences of VitE deficiency during development. Adult 5D wild-type zebrafish (<i>Danio rerio</i>), fed defined diets without (E-) or with VitE (E+, 500 mg <i>RRR</i>-α-tocopheryl acetate/kg diet), were spawned to obtain E- and E+ embryos that we evaluated using metabolomics and specific lipid analyses (each measure at  ...[more]

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