COMT Val158Met Polymorphism and Symptom Improvement Following a Cognitively Focused Intervention for Irritable Bowel Syndrome.

ABSTRACT:

Background

Our nurse-delivered comprehensive self-management (CSM) program, a cognitive behavioral therapy intervention, is effective in reducing gastrointestinal and psychological distress symptoms in patients with irritable bowel syndrome (IBS). Findings from non-IBS studies indicate that the catechol-O-methyltransferase (COMT) Val158Met polymorphism may moderate the efficacy of cognitive behavioral therapy. It is unknown whether this COMT polymorphism is associated with symptom improvements in patients with IBS.

Objective

We tested whether this COMT Val158Met polymorphism influences the efficacy of our 2-month CSM intervention.

Methods

We analyzed data from two published randomized controlled trials of CSM. The combined European American sample included 149 women a

SUBMITTER: Han CJ 

PROVIDER: S-EPMC5334775 | biostudies-literature | 2017 Mar/Apr

REPOSITORIES: biostudies-literature