Gene networks activated by specific patterns of action potentials in dorsal root ganglia neurons.

ABSTRACT: Gene regulatory networks underlie the long-term changes in cell specification, growth of synaptic connections, and adaptation that occur throughout neonatal and postnatal life. Here we show that the transcriptional response in neurons is exquisitely sensitive to the temporal nature of action potential firing patterns. Neurons were electrically stimulated with the same number of action potentials, but with different inter-burst intervals. We found that these subtle alterations in the timing of action potential firing differentially regulates hundreds of genes, across many functional categories, through the activation or repression of distinct transcriptional networks. Our results demonstrate that the transcriptional response in neurons to environmental stimuli, coded in the pattern of actio

SUBMITTER: Lee PR 

PROVIDER: S-EPMC5335607 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature