MART-10 represses cholangiocarcinoma cell growth and high vitamin D receptor expression indicates better prognosis for cholangiocarcinoma.

ABSTRACT: Cholangiocarcinoma (CCA) is a devastating disease due to no effective treatments available. Since the non-mineral functions of vitamin D emerges, 1α,25(OH)₂D₃, the active form of vitamin D, has been applied in anti-cancer researches. In this study, we demonstrated that both the 1α,25(OH)₂D₃ analog, MART-10, and 1α,25(OH)₂D₃ possessed anti-growth effect on human CCA cells with MART-10 much more potent than 1α,25(OH)₂D₃. The growth inhibition of both drugs were mediated by induction of G0/G1 cell cycle arrest through upregulation of p27 and downregulation of CDK4, CDK6, and cyclin D3. Human neutrophil gelatinase associated lipocalin (NGAL) was found to be involved in 1α,25(OH)₂D₃ and

SUBMITTER: Chiang KC 

PROVIDER: S-EPMC5335655 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature