Prediction of GCRV virus-host protein interactome based on structural motif-domain interactions.

ABSTRACT:

Background

Grass carp hemorrhagic disease, caused by grass carp reovirus (GCRV), is the most fatal causative agent in grass carp aquaculture. Protein-protein interactions between virus and host are one avenue through which GCRV can trigger infection and induce disease. Experimental approaches for the detection of host-virus interactome have many inherent limitations, and studies on protein-protein interactions between GCRV and its host remain rare.

Results

In this study, based on known motif-domain interaction information, we systematically predicted the GCRV virus-host protein interactome by using motif-domain interaction pair searching strategy. These proteins derived from different domain families and were predicted to interact with different motif patterns in GCRV. JAM-A

SUBMITTER: Zhang A 

PROVIDER: S-EPMC5335770 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature