Rapid and stable changes in maturation-related phenotypes of the adult hippocampal neurons by electroconvulsive treatment.

ABSTRACT: Electroconvulsive therapy (ECT) is a highly effective and fast-acting treatment for depression. Despite a long history of clinical use, its mechanism of action remains poorly understood. Recently, a novel cellular mechanism of antidepressant action has been proposed: the phenotype of mature brain neurons is transformed to immature-like one by antidepressant drug treatments. We show here that electroconvulsive stimulation (ECS), an animal model of ECT, causes profound changes in maturation-related phenotypes of neurons in the hippocampal dentate gyrus of adult mice. Single ECS immediately reduced expression of mature neuronal markers in almost entire population of dentate granule cells. After ECS treatments, granule cells showed some of physiological properties characteristic of immature gr

SUBMITTER: Imoto Y 

PROVIDER: S-EPMC5335812 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature