The effect of early life status epilepticus on ultrasonic vocalizations in mice.

ABSTRACT:

Objective

Infant crying is a series of innate vocal patterns intended to elicit the attention of adult caregivers for fulfillment of specific needs such as pain, hunger, or hypostimulation. It is one of the earliest forms of observable communication. In neonatal rodents, this behavior has recently been investigated as a potential early behavioral marker of neural deficits in neurodevelopmental disorders. However, few studies have examined the effects of seizures on vocalization behavior during the neonatal period. The purpose of this study is to investigate the effect of a single kainate-induced early life seizure on vocalization behavior in mice. This study also investigates the subsequent effect of seizures on two pathways critical for early neural development and epileptogenesis

SUBMITTER: Reynolds CD 

PROVIDER: S-EPMC5335835 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature