Zika virus infection of cellular components of the blood-retinal barriers: implications for viral associated congenital ocular disease.

ABSTRACT:

Background

Ocular abnormalities present in microcephalic infants with presumed Zika virus (ZIKV) congenital disease includes focal pigment mottling of the retina, chorioretinal atrophy, optic nerve abnormalities, and lens dislocation. Target cells in the ocular compartment for ZIKV infectivity are unknown. The cellular response of ocular cells to ZIKV infection has not been described. Mechanisms for viral dissemination in the ocular compartment of ZIKV-infected infants and adults have not been reported. Here, we identify target cells for ZIKV infectivity in both the inner and outer blood-retinal barriers (IBRB and OBRB), describe the cytokine expression profile in the IBRB after ZIKV exposure, and propose a mechanism for viral dissemination in the retina.

Methods

We expose p

SUBMITTER: Roach T 

PROVIDER: S-EPMC5335843 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature