Chromosomal abnormalities and molecular landscape of metastasizing mucinous salivary adenocarcinoma.

ABSTRACT:

Background

Mucinous adenocarcinoma of the salivary gland (MAC) is a lethal cancer with unknown molecular etiology and a high propensity to lymph node metastasis. Mostly due to its orphan status, MAC remains one of the least explored cancers that lacks cell lines and mouse models that could help translational and pre-clinical studies. Surgery with or without radiation remains the only treatment modality but poor overall survival (10-year, 44%) underscores the urgent need for mechanism-based therapies.

Methods

We developed the first patient-derived xenograft (PDX) model for pre-clinical MAC studies and a cell line that produces aggressively growing tumors after subcutaneous injection into nude mice. We performed cytogenetic, exome, and proteomic profiling of MAC to identify dr

SUBMITTER: Panaccione A 

PROVIDER: S-EPMC5335866 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature