Collagen-Gold Nanoparticle Conjugates for Versatile Biosensing.

ABSTRACT: Integration of noble metal nanoparticles with proteins offers promising potential to create a wide variety of biosensors that possess both improved selectivity and versatility. The multitude of functionalities that proteins offer coupled with the unique optical properties of noble metal nanoparticles can allow for the realization of simple, colorimetric sensors for a significantly larger range of targets. Herein, we integrate the structural protein collagen with 10 nm gold nanoparticles to develop a protein-nanoparticle conjugate which possess the functionality of the protein with the desired colorimetric properties of the nanoparticles. Applying the many interactions that collagen undergoes in the extracellular matrix, we are able to selectively detect both glucose and heparin with the sa

SUBMITTER: Unser S 

PROVIDER: S-EPMC5335965 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature