Dengue virus antibody database: Systematically linking serotype-specificity with epitope mapping in dengue virus.

ABSTRACT:

Background

A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a central role in dengue pathogenesis. Primary infections are typically associated with a largely serotype-specific antibody response, while secondary infections show a shift to a broadly cross-reactive antibody response.

Methods/principal findings

We hypothesized that the basis for the shift in serotype-specificity between primary and secondary infections can be found in a change in the antibody fine-specificity. To investigate the link between epitope- and serotype-specificity, we assembled the Dengue Virus Antibody Database, an online

SUBMITTER: Chaudhury S 

PROVIDER: S-EPMC5336305 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature