Transcriptional signatures of unfolded protein response implicate the limitation of animal models in pathophysiological studies.

ABSTRACT:

Background

The unfolded protein response (UPR) refers to intracellular stress signaling pathways that protect cells from the stress caused by accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER). The UPR signaling is crucially involved in the initiation and progression of a variety of human diseases by modulating transcriptional and translational programs of the stressed cells. In this study, we analyzed the gene expression signatures of primary stress sensors and major mediators of UPR pathways in a variety of tissues/organs of human and murine species.

Methods

We first analyzed protein sequence similarities of major UPR transducers and mediators of human and murine species, and then examined their gene expression profiles in 26 human and mouse c

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC5336312 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature