Systemic Levels of Estrogens and PGE₂ Synthesis in Relation to Postmenopausal Breast Cancer Risk.

ABSTRACT: Background: Prostaglandin E₂ (PGE₂) induces aromatase expression in adipose tissue, leading to increased estrogen production that may promote the development and progression of breast cancer. However, few studies have simultaneously investigated systemic levels of PGE₂ and estrogen in relation to postmenopausal breast cancer risk.Methods: Here, we determined urinary estrogen metabolites (EM) using mass spectrometry in a case-cohort study (295 incident breast cancer cases and 294 subcohort members), and using linear regression estimated the effect of urinary levels of a major PGE₂ metabolite (PGE-M) on EMs. HRs for the risk of developing breast cancer in relation to PGE-M and EMs were compared between Cox regression models with and w

SUBMITTER: Kim S 

PROVIDER: S-EPMC5336521 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature