Prevalence and Morbidity of Undiagnosed Celiac Disease From a Community-Based Study.

ABSTRACT:

Background & aims

Little is known about the prevalence and burden of undiagnosed celiac disease in individuals younger than age 50. We determined the prevalence and morbidity of undiagnosed celiac disease in individuals younger than age 50 in a community.

Methods

We tested sera from 31,255 residents of Olmsted County, Minnesota (<50 y), without a prior diagnosis of celiac disease assay using an assay for IgA against tissue transglutaminase; in subjects with positive test results, celiac disease was confirmed using an assay for endomysial IgA. We performed a nested case-control study to compare the proportion of comorbidities between undiagnosed cases of celiac disease and age- and sex-matched seronegative controls (1:2). Medical records were abstracted to identify potential

SUBMITTER: Choung RS 

PROVIDER: S-EPMC5337129 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature