Adiposity, post-diagnosis weight change, and risk of cardiovascular events among early-stage breast cancer survivors.

ABSTRACT:

Purpose

Little research examines whether adiposity or post-diagnosis weight changes influence Cardiovascular disease (CVD) among breast cancer patients for whom effects may differ due to treatment and recovery.

Methods

We studied Stage I-III breast cancer survivors 18 to  <80 years, without pre-existing CVD, diagnosed from 1997 to 2013 at Kaiser Permanente. Women reported weight at diagnosis and weight and waist circumference (WC) around 24 months post diagnosis. Using Cox models for time to incident coronary artery disease, heart failure, valve abnormality, arrhythmia, stroke, or CVD death, we examined at-diagnosis body mass index (BMI, n = 3109) and post-diagnosis WC (n = 1898) and weight change (n = 1903, stable, ±5 to  <10-lbs or ±≥10-lbs).

Results

Mean (SD) age w

SUBMITTER: Cespedes Feliciano EM 

PROVIDER: S-EPMC5337404 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature