Country of residence is associated with distinct inflammatory biomarker signatures in HIV-infected patients.

ABSTRACT:

Background

Inflammation and coagulation biomarkers are independent predictors of morbidity and mortality in HIV-infected patients. The impact of country of residence on these biomarkers is unknown and was investigated in persons at similar stages of HIV infection.

Methods

Cryopreserved plasma specimens were analysed from 267 ART-naive patients with CD4 cell counts <100 cells/μl from Mexico (n=124) and South Africa (n=143). Biomarkers were compared and dimension reduction analyses were performed to highlight biosignatures according to nationality, gender and tuberculosis co-infection.

Results

Mexican patients were significantly different from South Africans with regard to age, gender, CD4 cell count, haemoglobin, presence of AIDS-defining illness and prev

SUBMITTER: Manion M 

PROVIDER: S-EPMC5337418 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature