Novel baseline predictors of adverse events during oral immunotherapy in children with peanut allergy.

ABSTRACT:

Background

Though peanut oral immunotherapy (OIT) is a promising investigational therapy, its potential is limited by substantial adverse events (AEs), which are relatively understudied.

Objective

A retrospective analysis was conducted, pooling data from 3 pediatric peanut OIT trials, comprising the largest analysis of peanut OIT safety to date.

Methods

We pooled data from 104 children with peanut allergy from 3 peanut OIT studies. We catalogued AEs from parental reports, daily symptom diaries, and dose escalations. We included events that were considered likely related to OIT and identified potential baseline predictors of higher AE rates using generalized linear regression models.

Results

Eighty percent of subjects experienced likely related AEs during OIT (7

SUBMITTER: Virkud YV 

PROVIDER: S-EPMC5337444 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature