Facilitated Peptide Transport via the Mucosal Epithelium: Impact on Tolerance Induction.

ABSTRACT: A hallmark of autoimmunity is the breakdown of tolerance and generation of effector responses against self-antigens. Re-establishment of tolerance in autoimmune disorders was always the most desired treatment option; however, despite many efforts, clinical trials have been largely unsuccessful. This also applies to the generation of oral tolerance, which seems to be a default response type of the mucosa-associated lymphoid tissues to harmless antigens. In this study, we report improved efficacy of oral tolerance induction by coupling antigen with the newly identified mucosal carrier peptide 13C. Antigen coupled to 13C is efficiently taken up in the gastrointestinal tract and could be visualized in cells of the lamina propria. Oral, rectal, or nasal treatment effectively induced the prolife

SUBMITTER: Kenngott EE 

PROVIDER: S-EPMC5337492 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature