CD161⁺ Tconv and CD161⁺ Treg Share a Transcriptional and Functional Phenotype despite Limited Overlap in TCRβ Repertoire.

ABSTRACT: Human regulatory T cells (Treg) are important in immune regulation, but can also show plasticity in specific settings. CD161 is a lectin-like receptor and its expression identifies an effector-like Treg population. Here, we determined how CD161⁺ Treg relate to CD161⁺ conventional T cells (Tconv). Transcriptional profiling identified a shared transcriptional signature between CD161⁺ Tconv and CD161⁺ Treg, which is associated with T helper (Th)1 and Th17 cells, and tissue homing, including high expression of gut-homing receptors. Upon retinoic acid (RA) exposure, CD161⁺ T cells were more enriched for CCR9⁺ and integrin α4⁺β7⁺ cells than CD161^- T cells. In addition, CD161⁺ Tconv and C

SUBMITTER: Duurland CL 

PROVIDER: S-EPMC5337494 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature