Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session.

ABSTRACT:

Objectives

To investigate the pathophysiological pathways leading to symptoms elicitation in multiple chemical sensitivity (MCS) by comparing gene expression in MCS participants and healthy controls before and after a chemical exposure optimised to cause symptoms among MCS participants.The first hypothesis was that unexposed and symptom-free MCS participants have similar gene expression patterns to controls and a second hypothesis that MCS participants can be separated from controls based on differential gene expression upon a controlled n-butanol exposure.

Design

Participants were exposed to 3.7 ppm n-butanol while seated in a windowed exposure chamber for 60 min. A total of 26 genes involved in biochemical pathways found in the literature have been proposed to play a role

SUBMITTER: Dantoft TM 

PROVIDER: S-EPMC5337747 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature