IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections.

ABSTRACT: IL-10 is a potent anti-inflammatory mediator that plays a crucial role in limiting host immunopathology during bacterial infections by controlling effector T cell activation. Staphylococcus aureus has previously been shown to manipulate the IL-10 response as a mechanism of immune evasion during chronic systemic and biofilm models of infection. In the present study, we demonstrate divergent roles for IL-10 depending on the site of infection. During acute systemic S. aureus infection, IL-10 plays an important protective role and is required to prevent bacterial dissemination and host morbidity by controlling effector T cells and the associated downstream hyperactivation of inflammatory phagocytes, which are capable of host tissue damage. CD19⁺CD11b⁺CD5

SUBMITTER: Leech JM 

PROVIDER: S-EPMC5337812 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature