Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy.

ABSTRACT: Despite clear differences in immune system responses and in the prevalence of autoimmune diseases between males and females, there is little understanding of the processes involved. In this study, we identified a gene signature of immature-like neutrophils, characterized by the overexpression of genes encoding for several granule-containing proteins, which was found at higher levels (up to 3-fold) in young (20-30 y old) but not older (60 to >89 y old) males compared with females. Functional and phenotypic characterization of peripheral blood neutrophils revealed more mature and responsive neutrophils in young females, which also exhibited an elevated capacity in neutrophil extracellular trap formation at baseline and upon microbial or sterile autoimmune stimuli. The expression levels of th

SUBMITTER: Blazkova J 

PROVIDER: S-EPMC5337813 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature