Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells.

ABSTRACT: Circulating tumor cells (CTCs) play a crucial role in cancer dissemination and provide a promising source of blood-based markers. Understanding the spectrum of transcriptional profiles of CTCs and their corresponding regulatory mechanisms will allow for a more robust analysis of CTC phenotypes. The current challenge in CTC research is the acquisition of useful clinical information from the multitude of high-throughput studies. To gain a deeper understanding of CTC heterogeneity and identify genes, pathways and processes that are consistently affected across tumors, we mined the literature for gene expression profiles in CTCs. Through in silico analysis and the integration of CTC-specific genes, we found highly significant biological mechanisms and regulatory processes acting in CTCs across

SUBMITTER: Yadavalli S 

PROVIDER: S-EPMC5337960 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature