Continuous Flow ¹H and ¹³C NMR Spectroscopy in Microfluidic Stripline NMR Chips.

ABSTRACT: Microfluidic stripline NMR technology not only allows for NMR experiments to be performed on small sample volumes in the submicroliter range, but also experiments can easily be performed in continuous flow because of the stripline's favorable geometry. In this study we demonstrate the possibility of dual-channel operation of a microfluidic stripline NMR setup showing one- and two-dimensional ¹H, ¹³C and heteronuclear NMR experiments under continuous flow. We performed experiments on ethyl crotonate and menthol, using three different types of NMR chips aiming for straightforward microfluidic connectivity. The detection volumes are approximately 150 and 250 nL, while flow rates ranging from 0.5 μL/min to 15 μL/min have been employed. We show that in continuous flow the

SUBMITTER: Oosthoek-de Vries AJ 

PROVIDER: S-EPMC5337998 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature