Role of Fibrin(ogen) in Progression of Liver Disease: Guilt by Association?

ABSTRACT: Strong experimental evidence indicates that components of the hemostatic system, including thrombin, exacerbate diverse features of experimental liver disease. Clinical studies have also begun to address this connection and some studies have suggested that anticoagulants can improve outcome in patients with liver disease. Among the evidence of coagulation cascade activation in models of liver injury and disease is the frequent observation of thrombin-driven hepatic fibrin(ogen) deposition. Indeed, hepatic fibrin(ogen) deposition has long been recognized as a consequence of hepatic injury. Although commonly inferred as pathologic due to protective effects of anticoagulants in mouse models, the role of fibrin(ogen) in acute liver injury and chronic liver disease may not be universally detrim

SUBMITTER: Kopec AK 

PROVIDER: S-EPMC5338033 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature