Segmental duplications and evolutionary acquisition of UV damage response in the SPATA31 gene family of primates and humans.

ABSTRACT:

Background

Segmental duplications are an abundant source for novel gene functions and evolutionary adaptations. This mechanism of generating novelty was very active during the evolution of primates particularly in the human lineage. Here, we characterize the evolution and function of the SPATA31 gene family (former designation FAM75A), which was previously shown to be among the gene families with the strongest signal of positive selection in hominoids. The mouse homologue for this gene family is a single copy gene expressed during spermatogenesis.

Results

We show that in primates, the SPATA31 gene duplicated into SPATA31A and SPATA31C types and broadened the expression into many tissues. Each type became further segmentally duplicated in the line towards humans with the larg

SUBMITTER: Bekpen C 

PROVIDER: S-EPMC5338094 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature