Use of antipsychotics and risk of myocardial infarction: a systematic review and meta-analysis.

ABSTRACT:

Aim

There is emerging concern that antipsychotics may be associated with an increased risk of myocardial infarction (MI). A previous review identified five observational studies that did not provide an accurate estimate of the association between antipsychotic drug use and MI risk. More recent studies have produced variable results.

Methods

We performed a systematic review and meta-analysis of observational studies to determine whether antipsychotic use affects the risk for MI. Our analysis included all observational studies that compared MI incidence among patients receiving antipsychotics vs. no treatment.

Results

Nine observational studies were included in the analysis. The odds for developing MI were 1.88-fold higher (odds ratio (OR) 1.88, 95% confidence interval

SUBMITTER: Yu ZH 

PROVIDER: S-EPMC5338104 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature