Salivary caffeine concentrations are comparable to plasma concentrations in preterm infants receiving extended caffeine therapy.

ABSTRACT:

Aims

Caffeine concentrations in preterm infants are usually measured in the blood. However, salivary assays may provide a valid and practical alternative. The present study explored the validity and clinical utility of salivary caffeine concentrations as an alternative to blood concentrations and developed a novel plasma/salivary caffeine distribution model.

Methods

Paired salivary and plasma samples were obtained in 29 infants. Salivary samples were obtained using a commercially available salivary collection system. Caffeine concentrations in the saliva and plasma were determined using high-performance liquid chromatography. A population pharmacokinetic (PK) model was developed using NONMEM 7.3.

Results

The mean (± standard deviation) gestational age (GA) at birth an

SUBMITTER: Dobson NR 

PROVIDER: S-EPMC5338118 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature