The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta-analysis.

ABSTRACT:

Aims

Deprescribing is a suggested intervention to reverse the potential iatrogenic harms of inappropriate polypharmacy. The review aimed to determine whether or not deprescribing is a safe, effective and feasible intervention to modify mortality and health outcomes in older adults.

Methods

Specified databases were searched from inception to February 2015. Two researchers independently screened all retrieved articles for inclusion, assessed study quality and extracted data. Data were pooled using RevMan v5.3. Eligible studies included those where older adults had at least one medication deprescribed. The primary outcome was mortality. Secondary outcomes were adverse drug withdrawal events, psychological and physical health outcomes, quality of life, and medication usage (e.g.

SUBMITTER: Page AT 

PROVIDER: S-EPMC5338123 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature