Direct oral anticoagulants for stroke prevention in patients with atrial fibrillation: meta-analysis by geographic region with a focus on European patients.

ABSTRACT:

Aims

To analyse clinical outcomes with direct oral anticoagulants in patients with atrial fibrillation according to geographic region.

Methods

We systematically searched MEDLINE, CENTRAL, websites of regulatory agencies, clinical trials registers and conference proceedings for randomized controlled trials of direct oral anticoagulants (DOAC: dabigatran, rivaroxaban, apixaban or edoxaban) against warfarin for prophylaxis of stroke and systemic embolic events (SEE) in patients with atrial fibrillation (AF). Two investigators independently extracted data. Relative risks of stroke and SEE as well as major bleeding depending on geographic region were estimated using a random effect meta-analysis.

Results

Five trials in 72 963 patients were analysed; 32 089 (44%) patients w

SUBMITTER: Gomez-Outes A 

PROVIDER: S-EPMC5338130 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature