Population-based analysis of pathological correlates of dementia in the oldest old.

ABSTRACT:

Objective

The aim of this study was to analyze brain pathologies which cause dementia in the oldest old population.

Methods

All 601 persons aged ≥85 years living in the city of Vantaa (Finland), on April 1st, 1991 formed the study population of the Vantaa85 +  study, 300 of whom were autopsied during follow-up (79.5% females, mean age-at-death 92 ± 3.7 years). Alzheimer's disease (AD) pathology (tau and beta-amyloid [Aβ]), cerebral amyloid angiopathy (CAA) and Lewy-related pathologies were analyzed. Brain infarcts were categorized by size (<2 mm, 2-15 mm, >15 mm) and by location. Brain hemorrhages were classified as microscopic (<2 mm) and macroscopic.

Results

195/300 (65%) were demented. 194/195 (99%) of the demented had at least one neuropathology. Three inde

SUBMITTER: Tanskanen M 

PROVIDER: S-EPMC5338150 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature