Systematic review and meta-analysis of clinical outcomes of early caffeine therapy in preterm neonates.

ABSTRACT:

Aims

This study evaluated the therapeutic outcomes of early versus late caffeine therapy in preterm neonates.

Methods

We performed a systematic literature search in PubMed, Embase, CINAHL and CENTRAL from inception to 30 June 2016 to identify studies investigating the use of early caffeine therapy (initiated at less than 3 days of life) in preterm infants. Effect estimates were combined using random-effects meta-analysis. The primary outcomes for this study were bronchopulmonary dysplasia and mortality.

Results

The initial search found 4066 citations, of which 14 studies enrolling a total of 64 438 participants were included. The time of initiation of early caffeine therapy varied from the first 2 h to 3 days postnatal. Early caffeine therapy reduced the risk of bronc

SUBMITTER: Kua KP 

PROVIDER: S-EPMC5338164 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature