Optimizing image registration and infarct definition in stroke research.

ABSTRACT:

Objective

Accurate representation of final infarct volume is essential for assessing the efficacy of stroke interventions in imaging-based studies. This study defines the impact of image registration methods used at different timepoints following stroke, and the implications for infarct definition in stroke research.

Methods

Patients presenting with acute ischemic stroke were imaged serially using magnetic resonance imaging. Infarct volume was defined manually using four metrics: 24-h b1000 imaging; 1-week and 1-month T2-weighted FLAIR; and automatically using predefined thresholds of ADC at 24 h. Infarct overlap statistics and volumes were compared across timepoints following both rigid body and nonlinear image registration to the presenting MRI. The effect of nonlinear reg

SUBMITTER: Harston GW 

PROVIDER: S-EPMC5338168 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature